Drug Screening Platform
Single B cell technology
Technical features
Platform technical features: High throughput, high fidelity, high success rate
- High-throughput expression: Transferring single-copy B cell genes into HEK293 to express monoclonal antibodies.
- High-throughput sorting: Displaying antibody molecules on mammalian cells and using MACS and FACS technologies to achieve high-throughput single-cell sorting.
- High success rate: Secretion of full IgG by mammalian cell supernatants, completing 4-6 functional screenings, typically including binding, crossing, Koff, protein/cell-level blocking, and signaling pathways, with good drug potential and developability.
- High fidelity: Screening memory B cells and plasma cells to ensure natural pairing of B cell heavy and light chains.
Yeast display technology
Technical features
Full human natural library
Fully humanized mice
2027 healthy human donors
Fully human
Total PBMC count > 2.86×1010
High specificity
Proprietary scFv and Fab libraries
High affinity
